【摘要】 目的探讨血清泌乳素水平与育龄期女性系统性红斑狼疮病情活动性的相关性。方法选取2014年1月~2015年8月佛山市顺德区第一人民医院收治的90例育龄期女性系统性红斑狼疮(SLE)患者,其中活动期52例为A组,非活动期38例为B组,同时选取同期健康女性50例为对照(C组)。对三组进行清晨空腹抽血及SLEDAI评分,比较三组患者血清泌乳素(PRL)、补体C3、C4,抗ds-DNA抗体水平及SLEDAI评分。结果 A组和B组的血清PRL、抗ds-DNA抗体水平均明显高于C组,补体C3、C4水平则明显低于C组(P<0.01)。SLE患者中A组的血清PRL、抗ds-DNA抗体水平、SLEDAI评分又明显高于B组(P<0.01),补体C3水平明显低于B组(P<0.01);Pearson相关分析结果显示:血清PRL、抗ds-DNA抗体水平与SLEDAI评分呈正相关(r=0.656、0.786,P<0.01),补体C3水平与SLEDAI评分呈负相关(r=-0.529,P<0.01);抗ds-DNA抗体水平与血清PRL水平呈正相关(r=0.603,P<0.01),补体C3水平与血清PRL水平呈负相关(r=-0.472,P<0.01)。结论育龄期女性SLE患者的血清PRL水平相对于健康育龄期女性有明显上升,血清PRL水平和SLE疾病活动性呈明显正相关,血清PRL参与了SLE的发病过程。更多还原

【Abstract】 Objective To discuss the correlation between serum prolactin level and childbearing age women with systemic lupus erythematosus(SLE) disease activity. Methods From January 2014 to August 2015, in the First People’s Hospital of Shunde District, 90 childbearing age women with systemic lupus erythematosus were selected, 52 patients in activity period were as group A, 38 patients in non-activity period were as group B; at the same time, 50 healthy women were selected as control(group C). Three groups were given fasting blood in the morning and SLEDAI assessment, serum PRL, C3, C4, anti ds-DNA antibody and SLEDAI scores were compared between three groups. Results Serum PRL and anti ds-DNA antibody levels of group A and group B were significantly higher than those of group C(P <0.01), complement C3, C4 levels of group A and group B were significantly lower than those of group C(P < 0.01). The serum levels of PRL, anti ds-DNA antibody and SLEDAI score of group A were significantly higher than those of group B(P <0.01), the level of complement C3 of group A was significantly lower than that of group B(P < 0.0.1). Pearson related analysis showed: serum PRL, anti ds-DNA antibody level were positively correlated with SLEDAI score(r = 0.656, 0.786,P < 0.01), the level of complement C3 was negatively correlated with SLEDAI score(r =-0.529, P < 0.01); anti dsDNA antibody level was positively correlated with serum PRL level(r = 0.603, P < 0.01), the level of complement C3 was negatively correlated with serum PRL(r =-0.472, P < 0.01). Conclusion The serum level of PRL of childbearing age women with SLE is significantly higher than that of the healthy childbearing age women, serum PRL levels and SLE disease activity are significantly positively correlated, serum PRL is involved in the pathogenesis of SLE.更多还原