【摘要】 三阴性乳腺癌(TNBC)是指雌激素受体(ER)、孕激素受体(PR)及人类上皮细胞生长因子受体2(HER2)均无表达的一类乳腺癌,与其他乳腺癌相比,TNBC对新辅助化疗的完全病理缓解率较高,效果较好,然而,仍有超过半数的TNBC不能达到完全病理缓解,预后较差,目前,很多学者致力于研究细胞毒药物、靶向药物等对TNBC的治疗。针对不同亚型的TNBC,新辅助化疗的组合方式及有效的药物靶点、可靠的预后标志等将会是本领域研究的热点。更多还原

【Abstract】 Triple-negative breast cancer( TNBC) is defined by the lack of immunohistochemical expression of the estrogen receptors( ER),progesterone receptors( PR) and human epidermal growth factor receptor 2( HER2). Historically,TNBC has responded well in the neoadjuvant setting,with rates of pathological complete response commonly higher than for other breast tumor types. However,more than half of TNBC patients do not achieve a pathological complete response and have a poor prognosis. Many studies have addressed improving the efficacy of neoadjuvant chemotherapy by including different cytotoxic agents and targeted agents. For different subtypes of TNBC,combination of neoadjuvant chemotherapy,effective target and prognostic indicator will be the hot spot in the clinical study.更多还原