【摘要】 目的分析体素内不相干运动磁共振扩散加权成像（IVIM-DWI）和磁共振动态增强扫描（DCE-MRI）定量参数对前列腺癌和前列腺增生鉴别诊断的价值,探讨二者灌注系数的相关性,并对两种不同方法进行评价和比较。方法回顾性分析经病理学证实的31例前列腺癌患者和52例前列腺增生患者。所有患者均行前列腺IVIM-DWI和DCE-MRI检查,其中IVIM-DWI采用10个b值（b=10、20、30、50、80、100、200、400、1000、1500 s/mm²）,将所得图像通过工作站后处理,计算出病变组织的纯水分子扩散系数D值及灌注分数f值;同时将DCE-MRI扫描所得图像利用定量分析软件测量出病灶组织的参数值,即容积转运参数K^trans值、速率常数K_ep值及血管外细胞外容积分数Ve值。利用两独立样本t检验分别计算各参数在前列腺癌组和增生组间的差异;利用Person相关分析对两种不同检查方法中的灌注系数进行相关性分析;并对有鉴别诊断价值的参数行受试者特性曲线（ROC曲线）,评价各参数值的诊断效能。结果前列腺癌组的D值明显低于前列腺增生组,差异有统计学意义（P<0.01）;前列腺癌组的f值及K^trans、K_ep、Ve值明显高于前列腺增生组,差异有统计学意义（P<0.01）,且f值与K_ep值呈正相关（P<0.05）,其相关系数为0.368。对D、f值及Ktrans、Kep、Ve值分别行ROC曲线得出:Kep的曲线下面积（AUC）最大（0.991,P<0.01）,相应的敏感度和特异度分别为90.91%、100%。结论 IVIM-DWI和DCEMRI定量分析对前列腺良恶性疾病的诊断及鉴别诊断均有价值,两种不同检查方法的灌注系数呈正相关。DCE-MRI的诊断效能优于IVIM-DWI。更多还原

【Abstract】 Objective To assess the diagnostic value of parameters derived from Intravoxel incoherent motion diffusion-weighted imaging（IVIM-DWI） and dynamic contrast-enhanced（DCE）-MRI in prostate cancer and benign prostate hyperplasia and to explore the correlation of perfusion fraction between IVIM-DWI and DCE-MRI. Methods 83 patients with histologically confirmed prostate cancer（31） and prostate hyperplasia（52） underwent IVIM-DWI and DCE-MRI. The IVIM-DWI was performed with 10 b-values（10,20,30,50,80,100,200,400,1000, and 1500 s / mm²） to calculate the values of D and f. The values of K^trans, K_ep and Vewere measured on DCE-MRI. All parameters between prostate cancer and hyperplasia were compared by two independent sample t-test. The correlation of perfusion fraction between the two methods was analyzed by Pearson correlation. The diagnostic performance of different parameters was evaluated by receiver operating characteristic（ROC） curve analysis. Results The D value of prostate cancer was significantly lower than that of hyperplasia（P <0.01）. The values of f and Ktrans, Kep, Vewere significantly higher in cancer than hyperplasia（P <0.01）. F and K_ep were positively correlated（r =0.368）. With ROC curve analysis for the values of D, f,K^trans, K_ep, V_e, the area under the ROCcurve of Kepwas 0.991, significantly（P<0.01） larger than that of D,f,K^trans, and Vewith 90.91% diagnostic sensitivity and 100% specificity. Conclusion Both IVIM-DWI and DCE-MRI can improve the differential diagnosis of prostate disease with positive correlation of the perfusion fractions. DCE-MRI has better diagnostic performance than IVIM-DWI.更多还原