【摘要】 目的:探讨¹⁸F-脱氧葡萄糖(¹⁸F-fluorodeoxyglucose,¹⁸F-FDG)PET/CT联合血清糖类抗原125（carbohydrate antigen 125,CA125）及人附睾蛋白4（human epididymis protein 4,HE4）检测在卵巢癌术后复发和转移中的诊断价值。方法:回顾性分析63例卵巢癌患者术后PET/CT、CA125及HE4结果,与手术病理或临床随访资料相比较,判断三者对复发或转移性卵巢癌的诊断价值及相关性。结果:PET/CT诊断卵巢癌复发和转移的灵敏度、特异度、准确率、阳性预测值、阴性预测值分别为94.00%、84.62%、92.06%、95.92%、78.57%。CA125水平与复发和转移灶的最大标准摄取值（maximum standardized uptake value,SUVmax）呈正相关（r=0.428,P=0.002）。PET/CT联合HE4诊断卵巢癌复发和转移的灵敏度、特异度、准确率、阳性预测值、阴性预测值分别为98.00%、84.62%、95.24%、96.08%、91.67%。结论:在诊断卵巢癌复发和转移中,¹⁸F-FDG PET/CT联合HE4具有最高的诊断效能。更多还原

【Abstract】 Objective: To analyze and discuss the value of combination of ¹⁸F-fluorodeoxyglucose(¹⁸F-FDG) PET/CT and serum carbohydrate antigen 125（CA125） or human epididymis protein 4（HE4） in the diagnosis of recurrent or metastatic ovarian cancer. Methods: The postoperative results of PET/CT, serum CA125 and HE4 of 63 cases of ovarian cancer were analyzed retrospectively. The results were compared with surgical pathology or clinical follow-up data, so as to evaluate their values in the diagnosis of recurrent or metastatic ovarian cancer. Results: The overall sensitivity, specificity, accuracy, positive and negative predictive values of PET/CT were 94.00%, 84.62%, 92.06%, 95.92% and 78.57%. The corresponding values of combination of PET/CT and serum HE4 were 98.00%, 84.62%, 95.24%, 96.08% and 91.67%. CA125 level was positively correlated with maximum standardized uptake value（SUVmax） of the recurrent or metastatic region. Conclusion: The diagnostic efficiency of ¹⁸F-FDG PET/CT combined with HE4 is high in the diagnosis of recurrent or metastatic ovarian cancer.更多还原