【摘要】 目的通过分析新促排卵药雷洛昔芬(raloxifene,RAL)对着床窗期小鼠子宫内膜容受性标志物环氧合酶-2(cyclooxygenase 2,COX-2)和溶血磷脂酸受体3(lysophosphatidic acid receptor 3,LPAR3)表达的影响,探讨雷洛昔芬是否损害小鼠子宫内膜容受性。方法雌性昆明系小鼠60只,随机分为RAL用药促排卵组和自然受孕对照组。在雌鼠妊娠第4.5 d,采用免疫组化法检测COX-2和LPAR3在2组雌鼠子宫内膜中的表达。结果 COX-2、LPAR3 2个因子在RAL用药组和自然受孕对照组小鼠中的表达均无显著性差异,P>0.05。结论通过RAL用药来进行促排卵,对着床期小鼠子宫内膜COX-2和LPAR3表达水平的影响不明显,对子宫内膜容受性未发现产生不良损伤。更多还原

【Abstract】 Objective To explore the effect of ovulation induction by raloxifene treatment on endometrial receptivity by detection of the expression of COX-2 and LPAR3 in mouse endometrium during peri-implantation period. Methods 60 female non-pregnant Kunming mice were randomly divided into the RAL treatment group and the normal control group(natural conception). 4.5 days following pregnancy,the expression of COX-2 and LPAR3 in mouse endometrium was detected by immunohistochemical staining.Results There were no significant differences in the expression of COX- 2 and LPAR3 in mouse endometrium between the RAL group and the normal controlled group. Conclusion Raloxifene treatment for ovulation induction does not change the expression of COX- 2 and LPAR3 in mouse endometrium significantly,and has no harmful effects on the endometrial receptivity.更多还原