【摘要】 pH敏感性多肽类药物递送系统,以肿瘤组织酸性的细胞外环境为靶点,具有肿瘤特异性高、细胞毒性低,且能显著提高传统抗癌药物的活性等优点,近年来受到了广泛的关注。本文总结了5种类型靶向作用于肿瘤细胞的pH敏感性多肽类药物递送系统的研究进展,对今后肿瘤靶向型药物的设计和应用有重要意义。更多还原

【Abstract】 The pH-sensitive peptides drug delivery systems,which target to acidic extracellular environment of tumor tissue,have many advantages in drug delivery.They exhibit a high specificity to tumor and low cytotoxicity,which significantly increase the efficacy of traditional anti-cancer drugs.In recent years the systems have received a great attention.The pH-sensitive peptides drug delivery systems can be divided into five types according to the difference in pH-responsive mechanism,type of peptides and carrier materials.This paper summarizes the recent progresses in the field with a focus on the five types of pH-sensitive peptides in drug delivery systems.This may provide a guideline to design and application of tumor targeting drugs.更多还原