【摘要】 本文旨在研究纤维素类聚合物抑制超饱和状态下药物结晶的规律特征。主要利用模拟液态超饱和过程和制备超饱和药物固体,利用溶出仪测定不同时间点药物含量的方法,分析纤维素聚合物类型、加入量、离子强度和黏度对BCS II类模型药物吲哚美辛的结晶抑制影响。结果表明,HPMC E15具有最强的结晶抑制效应,聚合物加入量越多,抑制吲哚美辛结晶能力越强。聚合物黏度的减少和离子强度的增大会导致聚合物抑制吲哚美辛结晶能力的增强。本研究可对纤维素类聚合物抑制超饱和状态下药物结晶提供科学指导。更多还原

【Abstract】 This study aims to explore the characteristics of crystallization inhibition by cellulose polymers at the supersaturated states of drugs. The study was performed by simulating supersaturated process and preparing supersaturated drug solid, and was carried out by measuring the content of drugs at different time points using dissolution apparatus. The types, amounts, ionic intensity and viscosity of cellulose polymers were examined to assess the crystallization inhibition effect on BCS II class drug indomethacin. HPMC E15 exhibited the strongest crystallization inhibition effect. The more added, more obvious crystallization suppression was observed against indomethacin. The decrease in viscosity and increase in ionic intensity led to an enhanced inhibition. The research provides a scientific guide for the crystallization inhibition of supersaturated drug by cellulose polymers.更多还原