【摘要】 目的:设计一种基于影像建模、组织等效和3D打印技术的多模态椎骨骨折影像学仿真体模。方法:采集1例健康人腰椎影像样本的腰椎段CT影像序列,将原始DICOM图像导入Mimics交互式的医学影像控制系统软件进行椎骨、肾脏和软组织的三维重建,在重建模型中构建"一"字缝、"Y"字缝的椎骨峡部骨折模型。使用3D打印和组织等效技术打印等X线吸收密度的椎骨骨折模型,经CT、数字X线摄影(DR)多模成像,对模型CT值进行评估,验证体模仿真程度。结果:所获得的椎骨骨折体模在CT、DR下成像清晰,组织X线吸收系数等效于真实人体组织。结论:基于3D打印技术的多模态椎骨骨折体模可在CT和DR影像下获得,并可应用于有限元生物力学分析。模体制做成本低廉且快速,组织等效参数符合正常人体参数范围,能够有效仿真3种不同类型的椎骨峡部裂骨折等人体腹部病变。更多还原

【Abstract】 Objective To design a multi- model vertebral fracture simulation phantom based on medical image modeling,tissue equivalence and three- dimensional(3D) printing technology. Methods The lumbar vertebral CT image sequence of the human lumbar vertebral image sample of a healthy person was obtained. The original DICOM image was imported into Mimics interactive medical image control system software to reconstruct the 3D models of vertebra, kidney and soft tissue.Vertebrae spondylolysis fracture models of " Ⅰ " type slot and "Y" type slot were constructed in the reconstructed model.The vertebral fracture model of equivalent X- ray absorption density was printed by 3D printing and tissue equivalence technologies. The CT and digital radiography(DR) multi-modal imaging were applied to evaluate the CT values of model,and to verify the simulation degree of phantom. Results The images of vertebral fracture phantom were clear under CT and DR, and the X-ray absorption coefficient of the tissue was equivalent to that of the real human tissue. Conclusion The multimodal vertebral fracture phantom based on 3D printing technology can be obtained in CT and DR, and can be used for finite element biomechanical analysis. The phantom can be constructed quickly with less cost. The tissue equivalence parameters of phantom are in the range of normal human parameters. The phantom can efficiently simulate three different types of vertebral spondylolysis fracture and other abdominal diseases.更多还原