【摘要】 目的研究复方酸枣仁茯苓口服液改善小鼠睡眠作用。方法设2.5、5和15ml/kg·BW 3个剂量组和蒸馏水对照组。连续给予小鼠30d后,进行直接睡眠实验、延长戊巴比妥钠眠时间实验、戊巴比妥钠阈下剂量催眠实验和戊巴比妥钠睡眠潜伏期实验。结果 5和15ml/kg·BW 2个剂量组能延长戊巴比妥钠催眠小鼠的睡眠时间和缩短巴比妥钠催眠小鼠的入睡潜伏期(P<0.05),且无明显的直接睡眠作用,并对小鼠体重无不良影响。结论复方酸枣仁茯苓口服液对小鼠睡眠具有改善作用。更多还原

【Abstract】 Objective To study effect of zizyphi spinosae poria cocos oral compound on improving the sleep of mice.Methods The mice were randomly divided into four groups:2.5 ml/kg· BW,5ml/kg· BW,15 ml/kg· BW dose groups and distilled water control group.Mice were treated with the test substance continuously for 30 days.Then the sleep time induced directly,the prolonging sleeping time induced by pentobarbital sodium,the affecting mouse sleeping rate under the threshold hypnogenesis dosage of pentobarbital sodium,the affecting sleeping delitescence induced by pentobarbital sodium were observed. Results Compared with the distilled water control group,the sleeping time was prolonged and sleeping delitescence was shortened in mice hypnotized by pentobarbital sodium in 5 ml/kg ·BW,15 ml/kg· BW groups(P <0.05).No significant direct sleep-inducing effect and no significant adverse effect on body weight were observed in those two groups. Conclusion Zizyphi spinosae poria cocos oral compound can improve sleeping quality in mice.更多还原