【摘要】 目的分析特布他林雾化吸入辅助盐酸氨溴索治疗小儿重症肺炎的临床效果。方法采用随机数表法将2012年10月至2015年9月本院收治的96例重症肺炎患儿分为观察组与对照组,每组各48例。对照组患儿给予特布他林雾化吸入治疗,观察组患儿在对照组治疗基础上辅助盐酸氨溴索治疗。比较两组患儿临床疗效、不良反应发生情况、治疗后主要临床症状消失时间和体温恢复正常时间、住院时间及治疗前后C反应蛋白(CRP)、降钙素原(PCT)水平和白细胞(WBC)计数变化情况。结果观察组患儿治疗总有效率显著高于对照组(P<0.05)。两组患儿各不良反应发生率比较差异均无显著性(P>0.05)。观察组患儿主要临床症状消失时间、体温恢复正常时间及住院时间均显著短于对照组(P<0.05)。治疗后两组患儿CRP、PCT水平和WBC计数均较治疗前显著降低(P<0.05),且观察组患儿上述指标下降程度均大于对照组(P<0.05)。结论特布他林雾化吸入辅助盐酸氨溴索治疗小儿重症肺炎效果显著,能够有效改善患儿临床症状,提高治愈率,缩短主要临床症状消失时间,祛痰效果佳,值得临床推广应用。更多还原

【Abstract】 Objective To analyze the clinical effect of terbutaline inhalation combined with ambroxol hydrochloride in the treatment of children with severe pneumonia. Method 96 cases of children with severe pneumonia from October 2012 to September 2015 in our hospital were researched, according to the random number table method, they were divided into observation group and control group, 48 cases in each group. Control group children were treated by terbutaline inhalation. Observation group children were treated by terbutaline inhalation combined with ambroxol hydrochloride. Compared the clinical efficacy, adverse reactions, disappeared time of main clinical symptoms and time of body temperature returned to normal, hospital stay and changes in CRP, PCT and leukocyte count between the two groups. Result The total effective rate of observation group was significantly higher than control group(P < 0.05). There were no significant differences in the incidence of adverse reactions between the two groups(P > 0.05). The disappeared time of main clinical symptoms and time of body temperature returned to normal, hospital stay of observation group were significantly shorter than control group(P < 0.05). After treatment, the levels of CRP, PCT and leukocyte count in the two groups were significantly lower than before treatment(P < 0.05), observation group with the above indexes falling levels were greater than control group(P < 0.05). Conclusion Terbutaline inhalation combined with ambroxol hydrochloride in the treatment of children with severe pneumonia has a significant effect, can effectively improve the clinical symptoms and the cure rate, shorten the time of symptoms. At the same time, it has better expectorant effect, worthy of promotion.更多还原