【摘要】 中药槟榔Arecae Semen为棕榈科植物槟榔Areca catechu L.的干燥成熟种子,临床应用记载首见于南北朝,历代本草文献对槟榔的基原、功效、毒性、炮制、使用禁忌等多有论述。世界卫生组织国际癌症研究中心认定槟榔为一级致癌物,槟榔安全性问题日益引起社会关注。本文对历代本草中记载的槟榔毒性及用药风险因素进行了归纳分析,提出在安全性研究中应重点关注基原、配伍等对槟榔成分和不良反应的影响,为进一步研究提供线索。更多还原

【Abstract】 Traditional Chinese medicine Arecae Semen is dried seed of Areca catechu L. Its clinical application records were first discovered in literatures of the Northern and Southern dynasty. The origins, efficacy, toxicity, processing and taboos of Arecae Semen have been discussed in many ancient herb literatures. The Arecae Semen was identified as a carcinogen by the International Agency for Research on Cancer(IRAC), and the safety of Arecae Semen has increasingly attracted attention of the society. In this paper, the authors summarized and analyzed the toxicity and medication risk factors of Arecae Semen recorded in ancient herb literatures, and proposed that more attention shall be paid to the effect of the origins and the compatibility on the components and toxicity of Arecae Semen in safety studies, which provides clues for the further studies.更多还原