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IL-21预测HBeAg阳性慢性乙型肝炎患者干扰素治疗应答的价值

Role of serum IL-21 level in predicting outcomes of interferon therapy in patients with HBeAg positive chronic hepatitis B

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【作者】 王霞李彦刘瑞霞傅涓涓成立伟李丽潘修成

【Author】 WANG Xia;LI Yan;LIU Ruixia;Department of Infectious Diseases,Affiliated Hospital,Xuzhou Medical College;

【机构】 徐州医学院附属医院感染病科

【摘要】 目的探讨IL-21水平在预测干扰素(IFN)治疗慢性乙型肝炎(CHB)疗效中的价值。方法 69例HBeAg阳性CHB患者接受IFN治疗48周。ELISA法检测治疗前和治疗12、24、36、48周外周血清IL-21水平,化学发光微粒子免疫检测法定量检测血清HBVM,荧光定量PCR检测血清HBV DNA水平。结果治疗48周时,22例(31.9%)为完全应答(CR)状态,出现HBeAg血清学转换,且HBV DNA<500IU/ml;其余47例(68.1%)为非完全应答(NCR)状态。CR组基线血清IL-21水平高于NCR组(P<0.05)。基线IL-21≥110pg/ml对CR的预测价值达到66.7%;其中,IL-21≥110pg/ml,且HBsAg定量≤3.84log10IU/ml的CHB患者中80.0%能够实现CR。结论治疗前血清IL-21高表达的HBeAg阳性CHB患者预示IFN治疗效果较好。

【Abstract】 Objective To explore the role of serum IL-21 levels in predicting the outcomes of interferon(IFN)therapy in the patients with HBeAg positive chronic hepatitis B(CHB).Methods Sixty-nine CHB patients with HBeAg positive were treated with IFN for 48 weeks.Serum levels of IL-21 were detected by ELISA before and in the 12th,24th,36 th,and 48 th week of IFN treatment.Serum level of HBV-M was detected by chemiluminescent micropartical immunoassay and that of HBV DNA was detected by fluorescence quantitative PCR.Results Of 69 patients,22 cases(31.9%)had complete response(group CR)to IFN therapy with HBeAg disapprearance,HBeAb apprearance and HBV DNA<500IU/ml.Another 47cases(68.1%)had no complete response(group NCR).Serum level of IL-21 before treatment was significantly higher in group CR than that in group NCR(P<0.05).Before treatment,66.7% of CR patients had serum IL-21levels≥110pg/ml and 80.0%of them had serum IL-21levels≥110pg/ml as well as HBsAg levels≤3.84log10 IU/ml.Conclusion High expression of serum IL-21 predicts a better efficacy of IFN therapy in CHB patients with HBeAg positive.

【基金】 江苏省临床医学科技专项(BL2012043)
  • 【文献出处】 江苏医药 ,Jiangsu Medical Journal , 编辑部邮箱 ,2016年05期
  • 【分类号】R512.62
  • 【被引频次】1
  • 【下载频次】41
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