Objective To investigate the possible role of bortezomib on the polarization of Th1 / Th2 / Th17 cells and the expression of IFN-γ,IL-4 and IL-17 A in mice with acute graft versus host disease( a GVHD). Methods To establish the animal model of mouse a GVHD,mice were randomly divided into 3 groups,normal control group,transplantation control group,transplantation and early injection bortezomib group. The survival time,clinical manifestations of a GVHD and levels of recipients H-2b cells detected by flow cyto...
【基金】
安徽省教育厅自然科学项目(编号:Kj2011Z165)
【更新日期】
2016-07-14
【分类号】
R457.7
【正文快照】
2016-03-25接收异基因造血干细胞移植是治疗恶性血液病和某些非恶性遗传性缺陷病的最有效方法之一,但移植后急性移植物抗宿主病(acute graft-versus-host dis-ease,a GVHD)的发生率高达20%~80%,是造成患者死亡和生活质量下降的主要原因之一[1]。因此,寻找新的药物和方法防治a G