【摘要】 目的了解2011-2013年河南省洛阳市疑似预防接种异常反应(AEFI)的发生特征,评价疫苗质量和预防接种的安全性。方法通过《全国疑似预防接种异常反应信息管理系统》收集2011-2013年洛阳市AEFI监测数据,采用描述流行病学的进行分析。结果 2011-2013年洛阳市报告AEFI分别为65例、328例和560例,共953例,县区覆盖率100%,48 h内报告率分别为84.6%、86.3%和91.6%,48 h内调查率为90.0%、94.1%和93.9%,3 d内调查表报告率分别为50.0%、70.6%和77.3%,分类率均为100%,≤1岁儿童占70.7%,6~8月份以及12月份是高发季节,接种后≤1 d占84.1%,接种疫苗第1剂次占65.8%。其中一般反应占95.0%,异常反应占3.5%,偶合症占1.3%,其他占0.3%,无心因性反应、接种事故和疫苗质量事故。引起AEFI疫苗共有31种,国家免疫规划(NIP)疫苗和非NIP疫苗引起的一般反应和异常反应的构成比无差异。发热、局部红肿和硬结为主要临床症状,预防接种异常反应以卡介苗淋巴结炎、过敏性皮疹为主。结论洛阳市AEFI的监测质量有所提高;绝大部分AEFI预后良好;AEFI的发生水平在预期的范围之内。更多还原

【Abstract】 Objective To understand the epidemic characteristics of adverse events following immunization( AEFI) in Luoyang city during 2011-2013,and to evaluate the vaccine quality and the safety of vaccination.Methods By The information system of national AEFI,surveillance data during 2011-2013 in Luoyang were collected and were analyzed with descriptive epidemiology. Results During 2011-2013 there were 65,328 and560 cases were reported annually in Luoyang,reaching a total number of 953,and the covering rate was100%. The 48 h report rate was respectively 84. 6%,86. 3% and 91. 6%,the 48 h survey rate were respectively 90. 0%,94. 1% and 93. 9%,the 3d survey report rate was 50. 0%,70. 6% and 77. 3%. The classification rate were all 100%,among which those with age no more than one year accounted for 70. 7% and June to August,and December were the high prevalence season. Those with no more than one day accounted for 84. 1%,those of one dose accounted for 65. 8%. There were 95% normal reaction,3. 5% adverse reaction,1. 3% coupled disease and 0. 3% other. No psychogenic reaction,inoculation accident and vaccine quality accidents were reported. There were 31 AEFI reported and the constituent ratio showed no statistical difference between NIP and non-NIP. The major clinical symptoms were mainly fever,partial red and swollen and scleroma. The AEFI were mainly lymphnoditis caused by bacillus calmette guerin vaccine and allergic eruption. Conclusion The surveillance quality of AEFI has to be improved. Most of the AEFI shows good prognosis and the occurrence level is in the presumptive range.更多还原