【摘要】 目的比较门冬胰岛素和生物合成人胰岛素治疗妊娠期糖尿病(GDM)的疗效及对妊娠结局的影响。方法选择需胰岛素治疗的GDM孕妇63例,研究组32例采用门冬胰岛素治疗,对照组31例采用诺和灵治疗。结果研究组孕32周时的空腹血糖、餐后2 h血糖显著低于对照组(P<0.05,P<0.01),两组分娩前的空腹血糖及餐后2 h血糖比较无统计学差异(P>0.05)。两组的妊娠结局比较差异无统计学意义(P>0.05),研究组用药期间低血糖发生率显著低于对照组(P<0.05)。结论门冬胰岛素和生物合成人胰岛素用于妊娠期糖尿病治疗的疗效相当,妊娠结局相似,但门冬胰岛素临床副反应小,调整血糖达标时间更快。更多还原

【Abstract】 Objective To compare the effects and pregnancy outcomes of Novo Rapid and Novolin R in the treatment of gestational diabetes mellitus(GDM). Methods In 63 cases of GDM pregnancy women, 32 cases of study group were treated with Novo Rapid, and 31 cases of control group were treated with Novolin R. Results The levels of fasting blood glucose and 2-hour postprandial blood glucose at 32 weeks of pregnancy in study group were significantly lower than those in control group(P <0.05, P <0.01), while no statistical difference was found between two groups before delivery(P >0.05). The pregnancy outcomes had no statistical difference between two groups(P >0.05);The incidence of hypoglycemia during drug use in the study group was significantly lower than that in the control group(P <0.05).Conclusions Novo Rapid and Novolin R have equivalent effects and similar pregnancy outcomes for the treatment of GDM patients.Novo Rapid is faster in blood glucose adjustment than Novolin R, and has fewer side reactions.更多还原