【摘要】 肺动脉高压(PAH)是一种复杂的闭塞性血管疾病。近十年的研究发现,PAH发病机理是基于肺内动脉血管壁抗凋亡和增殖环境的变化而不是血管收缩。虽然对于肺动脉高压的研究取得了很大进展,但它仍然是一种致死率很高的疾病。肺动脉高压在肺外组织出现病变包括右心室、骨骼肌、免疫系统以及骨髓等,使人们意识到PAH可能是一种全身性疾病,但目前应用于治疗PAH的药物都是局限于其舒张血管的特性。本文就PAH治疗的新近研究成果进展作一综述。更多还原

【Abstract】 Pulmonary arterial hypertension(PAH) is a complex occlusive vascular disease. Over the past decade, it is found that the pathogenesis of PAH is based on anti-apoptotic and proliferative changes rather than vasoconstriction in the pulmonary arterial wall.Research on pulmonary hypertension has made significant progress, but PAH is still a disease with high lethality. Pulmonary arterial hypertension occurs in extra-pulmonary tissues, including right ventricle, skeletal muscle, immune system, and bone marrow, which makes people come to realize that PAH may be a systemic disease, but currently available drugs for treatment of PAH are limited in its vasodilator characteristic. This paper reviewed the results and progress of recent studies on the treatment of pulmonary arterial hypertension.更多还原