【摘要】 目的评价本院治疗Ig A肾病的用药合理性,为其合理使用提供建议。方法采用用药频度分析性法对本院2013~2015年3年期间的共242张临床诊断为Ig A肾病的处方进行用药合理性分析。结果共收集本院242张处方,其中包括2013年60张,2014年55张,2015年127张。中成药用药频度(DDDs)正逐年上升,糖皮质激素用药频度有所下降;醋酸泼尼松片3年来用药频度均名列前三,降压药ACEI类和ARB类用药频度也位居前十。糖皮激素类药物、硝苯地平控释片和一些PPI类药物的DUI值大于1。结论本院以糖皮激素和干预RAS通路的降压药为Ig A肾病的主要治疗手段;中成药的使用呈增长趋势,其应用均合理;奥美拉唑肠溶片和硝苯地平控释片用药频度过高,存在滥用现象,建议按说明书和相关疾病指南调整用药方案,其余药品的使用均合理。更多还原

【Abstract】 OBJECTIVE To evaluate the rationality of medication for Ig A nephropathy during 2013-2015 in a hospital,and give some advices on rational drug application. METHODS Frequency analysis method was used to analyze the medication rationality of242 prescriptions for Ig A nephropathy during 2013-2015 in a hospital. RESULTS DDDs of the Chinese patent medicine was increasing gradually,while DDDs of glucocorticoid declined in recent years. DDDs of prednisone tablet always ranked in the top 3,while ACEI and ARB always ranked in the top 10 in recent years. DUI of glucocorticoid and nifedipine controlled-release tablets and some PPI were larger than 1. CONCLUSION Glucocorticoid and Antihypertensive agents acting on RAS pathway were the main treatment for Ig A nephropathy which could delay the proceeding of renal failure by reducing proteinuria and lowering blood pressure,the utilization of Chinese patent medicine tended to increase,but usage of which was rational,the using frequencies of omeprazole entericcoated tablets and nifedipine controlled-release tablets were higher than normal, there were some abuse phenomenon, it was recommended to follow the directions and guidelines to adjust medication. The utilization of other drugs was rational.更多还原