Aim To investigate the anti-tumor effects of FS-108 an Hsp90 inhibitor,on oncogene addicted EBC-1 and A375 cells. Methods SRB assay was performed to investigate cell proliferation. Immunoblot was conducted to investigate the specific proteins.FACS was conducted to test cell cycle distribution and apoptosis. Transwell assay was conducted to investigate cell motility. Results FS-108 significantly suppressed cell proliferation of EBC-1 and A375 cancer cells with IC_(50) at 25. 53 nmol·L~(-1) and 30. 02 nmol·L~...
【基金】
国家自然科学基金资助项目(No 9122920)
【更新日期】
2017-02-02
【分类号】
R730.2
【正文快照】
caspase-3;迁移随着人们对肿瘤分子生物学机制的逐渐认识,分子靶向治疗理念日益兴起,开发新的药物靶点、研发分子靶向药物成为肿瘤治疗的重要研究方向[1]。热休克蛋白90(heat short protein 90,Hsp90)作为分子伴侣在维持其客户蛋白的分子构象及稳定性等方面发挥重要作用[2-3]。
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