【摘要】 目的探讨单向式完全胸腔镜下(c-VATS)肺癌根治术治疗早期非小细胞肺癌(NSCLC)的远期疗效及预后相关影响因素。方法选取早期NSCLC患者56例为研究对象,均行单向式c-VATS肺癌根治术,观察患者手术情况及术后3、5年生存率,对患者进行长期规律随访,对可能影响患者预后的因素进行考察分析。结果本研究56例患者均顺利完成手术,无围术期死亡病例。术中无大出血,术后无肺动脉栓塞、肺部感染等并发症发生。术后随访时间2~65个月,中位总生存期为38个月,3年生存率为64.3%(36/56),5年生存率为48.2%(27/56)。单因素及多因素分析结果显示,病理分期、术后有无规范放疗、肿瘤直径及脉管内栓瘤与术后3年、5年生存情况有显著相关性(P<0.05)。结论单向式c-VATS肺癌根治术用于早期NSCLC患者安全有效,生存期长,病理分期、术后有无规范放疗、肿瘤直径及脉管内栓瘤是患者预后的相关因素。更多还原

【Abstract】 Objective To explore the long-term efficacy of unidirectional complete video-assisted thoracoscopic surgery( c-VATS) guided radical resection for lung cancer and prognostic influencing factors. Methods A total of 56 patients with early non-small cell lung cancer( NSCLC) were selected as study subjects,and given unidirectional c-VATS guided radical resection for lung cancer.Surgical condition and 3- and 5-year survival rates were observed,long-term regular follow up was conducted,and influencing factors for prognosis were analyzed. Results All of the 56 patients finished the surgery successfully,none died in peri-operative period. There was no massive intra-operative hemorrhage and postoperative pulmonary embolism and pulmonary infection. Postoperative followup period was 2 ~ 65 months,and median overall time was 38 months. And 3- and 5-year survival rates were 64. 3%( 36 /56) and 48. 2%( 27 /56),respectively. Univariate and multivariate analysis results showed that pathological patterns,whether there was postoperative specific radiotherapy,tumor diameter and intravascular tumor embolus had significant association with postoperative 3- and 5-year survival conditions( P < 0. 05). Conclusion Unidirectional c-VATS guided radical resection for lung cancer is safe and effective and long in survival time in the treatment of early NSCLC patients.Pathological patterns,whether there was postoperative specific radiotherapy,tumor diameter andintravascular tumor embolus are influencing factors for patients’ prognosis.更多还原