【摘要】 目的探讨静脉滴注丙种球蛋白（IVIG）治疗儿童传染性单核细胞增多症（IM）的临床疗效及对T淋巴细胞亚群的影响。方法 IM患儿76例随机分为对照组和观察组,各38例,同时选取38例体检正常儿童为健康组。对照组采用病毒唑治疗,观察组在对照组基础上加用静脉注射IVIG治疗。观察2组临床症状改善时间,对比临床疗效、治疗前后外周血中T淋巴细胞亚群的变化及不良反应发生情况。结果与对照组比较,观察组体温降低、肝脾及淋巴结缩小至正常的时间均降低（P<0.05或P<0.01）,观察组有效率为81.58%（31/38）,显著高于对照组的57.89%（22/38）,差异有统计学意义（P<0.05）;治疗后,2组CD₃及CD₈水平降低、CD₄及CD₄/CD₈均较治疗前升高（P<0.05或P<0.01）,观察组各指标与健康组无显著差异（P>0.05）。结论 IVIG免疫干预治疗能有效改善传染性单核细胞增多症患儿机体免疫能力,临床疗效优于单纯抗病毒治疗。更多还原

【Abstract】 Objective To investigate the efficacy of intravenous immunoglobulin（ IVIG）in treatment of children with infectious mononucleosis（ IM） and its influence on T lymphocyte subpopulation. Methods A total of 76 IM children were randomly divided into control group（ n = 38）and observation group（ n = 38）,and another 38 health children were selected as healthy control group. All IM children were given ribavirin therapy,and the observation group was treated with IVIG additionally. The time of symptoms improvement,clinical efficacy,adverse reactions and changes of T lymphocyte subpopulation before and after treatment were compared between the two groups. Results Recovery time of body temperature,hepatomegaly,splenomegaly and lymphadenectasis were significantly shorter in observation group than the control group（ P < 0. 05 or P < 0. 01）. The overall effective rate was 81. 58%（ 31 /38） in observation group and 57. 89%（ 22 /38） in control group,and there was a significant difference（ P < 0. 05）. The levels of CD₃ and CD₈decreased,and the CD₄ and ratio of CD₄/ CD₈ increased significantly in observation group and control group after treatment（ P < 0. 05 or P < 0. 01）. There was no significant differences in CD₃,CD₄,CD₈ and CD₄/ CD₈ between two groups after treatment（ P > 0. 05）. Conclusion Immunologic intervention of IVIG combined with antiviral agent shows better therapeutic effect on body immunity of children with IM.更多还原