【摘要】 目的了解东莞地区健康体检人群血尿酸水平及相关危险因素。方法对2012年至2014年21 452名健康体检者的血尿酸水平的分布情况进行分析,并收集资料完整的8 229名健康体检者,对其血尿酸、血清肌酐、总胆固醇、甘油三酯、LDL-C、HDL-C、空腹血糖、收缩压、舒张压资料进行统计学分析。结果东莞市体检人群高尿酸血症患病率男性为31.33%,女性为11.51%。男女比较差异有统计学意义(P<0.05)。高尿酸血症组血清肌酐、甘油三酯、LDL-C、HDL-C、空腹血糖、收缩压、舒张压水平均明显高于血尿酸正常组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示血脂升高、血压增高和血清肌酐升高是尿酸增高的危险因素。结论东莞市健康体检人群的男性和绝经后女性高尿酸血症患病率较高,应加强对正常人群的健康教育工作,有效防治高尿酸血症。更多还原

【Abstract】 Objective To explore the blood uric acid levels and risk factors of the population in Dongguan during physical examination. Methods The distribution of blood uric acid levels in 21 452 individuals who received physical examination between 2012 and 2014 was retrospectively analyzed. The serum uric acid,serum creatinine,total cholesterol,triglyceride,low density lipoprotein cholesterol( LDL-C),high density lipoprotein cholesterol( HDL-C),fasting plasma glucose,systolic and diastolic blood pressure of 8 229 participants with complete clinical data were statistically analyzed. Results The prevalence of hyperuricemia in the male individuals was 31. 33%,significantly higher compared with 11. 51% in the female population( P< 0. 05). The levels of serum creatinine,triglyceride,LDL-C,HDL-C,fasting plasma glucose,systolic and diastolic blood pressure in the hyperuricemia group were significantly higher than those in the normal group( all P < 0. 05). Multivariate logistic regression analysis revealed that hyperlipidemia,hypertension and elevated level of serum creatinine were risk factors of increased risk of hyperuricemia. Conclusions The prevalence of hyperunicemia is relatively high in the male and postmenopausal female population in Dongguan. Health education should be strengthened for the healthy subjects to effectively prevent the incidence of hyperuricemia.更多还原