【摘要】 目的了解广州市花都区健康体检人群中高尿酸血症(HUA)患者的分布特点以及合并高血压病、肥胖、糖尿病、高脂血症及肾功能减退的情况。方法收集2010年1月1日至2015年6月30日在广州市花都区人民医院健康体检中发现的HUA患者资料,总结其一般人口学资料、血清尿酸、血清肌酐、血清甘油三酯、血清胆固醇和血压的检测结果,统计、分析HUA患者的性别、年龄分布特点,分析不同血清尿酸水平的HUA患者合并糖尿病、肥胖、高脂血症、肾功能减退和高血压病的情况。结果共检出HUA患者26 396例,男女比例5.70∶1。与血清尿酸正常者相比,HUA患者年龄较大,BMI、血清尿酸、空腹血糖、LDL较高,GFR较低(P均<0.01)。与女性HUA患者相比,男性HUA患者的年龄较大、血清尿酸水平较高(P均<0.01)。HUA患者的血清尿酸水平随年龄增长而升高(P均<0.01)。26 396例HUA患者中,合并高血压病18 348例(69.51%)、糖尿病1 027例(3.89%)、肥胖12 813例(48.54%)、肾功能减退578例(2.19%)、高脂血症14 990例(56.79%)。男性HUA患者合并糖尿病、肥胖的比例高于女性(P均<0.01),而女性HUA患者合并肾功能减退的比例高于男性(P<0.01)。当血清尿酸水平升高至500μmol/L以上时,HUA患者合并糖尿病、肥胖及肾功能减退的比例明显升高(P均<0.005)。结论 HUA患者中男性多于女性,且多合并高血压病、高脂血症及肥胖。随着血清尿酸水平升高,HUA患者发生糖尿病、肥胖及肾功能减退风险升高。更多还原

【Abstract】 Objective To investigate the distribution characteristics of hyperuricemia( HUA) patients and relevant complications with hypertension,obesity,diabetes mellitus,hyperlipidemia and renal deficiency in the physical examination population from Huadu District,Guangzhou. Methods Clinical data of patients who were diagnosed with HUA during physical examination in Huadu People’s Hospital between January1,2010 and June 30,2015 were collected. Demographic data,serum uric acid,creatinine,triglyceride,cholesterol and blood pressure were measured. The distribution characteristics of age and gender in HUA patients were analyzed. The incidence of complications including diabetes mellitus,obesity,hyperlipidemia,renal deficiency and hypertension in patients with different levels of uric acid was investigated. Results A total of26396 patients were included with a male-to-female ratio of 5. 70∶ 1. Compared with those with normal uric acid levels,HUA patients were significantly older,had significantly higher BMI,serum uric acid,fasting blood glucose and LDL and significantly lower GFR( all P < 0. 01). Male HUA patients were older and had significantly higher uric acid levels compared with female counterparts( both P < 0. 01). Serum uric acid level was considerably increased over aging in HUA patients( P < 0. 01). Among all participants,18 348 cases( 69. 51%)were complicated with hypertension,1 027( 3. 89%) with diabetes mellitus,12 813( 48. 54%) with obesity,578( 2. 19%) with renal deficiency and 14 990( 56. 79%) with hyperlipidemia. The percentage of male patients complicated with diabetes mellitus and obesity was significantly higher whereas the proportion of renal deficiency was dramatically lower compared with those of female counterparts( all P < 0. 01). When uric acid level exceeded 500 μmol / L,the percentage of HUA patients complicated with diabetes mellitus,obesity and renal deficiency was significantly enhanced( all P < 0. 005). Conclusions Compared with female HUA patients,male counterparts were more likely to suffer from HUA,and be complicated with hypertension,hyperlipidemia and obesity. Along with the elevation in uric acid level,the risk of diabetes mellitus,obesity and renal deficiency in HUA patients was enhanced.更多还原