【摘要】 CD36属于跨膜糖蛋白,是一种多配体的受体,具有多种生物学功能。CD36缺失者可能通过输血、妊娠及器官移植等免疫途径刺激机体产生抗CD36同种免疫抗体,导致免疫性的血小板输注无效等疾病。本文就近几年来CD36缺失与其分子生物学基础、血小板输注及CD36抗体检测方法等方面的研究进展进行综述。更多还原

【Abstract】 CD36 is a transmembrane glycoprotein,a multi-ligand receptor,possesses various biological functions.CD36 deficiency may stimulate the body to produce anti-CD36 alloimmune antibodies through the several pathw ays,such as blood transfusion,pregnancy or organ transplantation and so on,leading to the refractoriness of immune platelet transfusion and other diseases. The recent research advances of CD36 deficiency and its molecular biological basis,platelet transfusion and CD36 antibody detection are summarized briefey in this review.更多还原