【摘要】 目的观察复方苦参注射液联合同步放化疗治疗局部晚期胃癌的近期临床效果。方法将65例局部晚期胃癌初治患者随机分为治疗组33例和对照组32例。对照组采用适形调强放疗同步卡培他滨化疗,治疗组在对照组基础上同时给予复方苦参注射液20 m L/次,1次/d,连续5周。观察2组患者近期疗效、生活质量、不良反应。结果治疗组近期疗效有效率为66.67%(22/33),对照组为40.63%(13/32),差异有统计学意义(P=0.031)。血液毒性不良反应中,治疗组白细胞下降发生率为30.30%(10/33),对照组为65.63%(21/32),差异有统计学意义(P=0.004)。治疗组卡氏评分升高26例(78.79%),对照组升高18例(56.25%),差异有统计学意义(P=0.046)。结论复方苦参注射液联合同步放化疗治疗局部晚期胃癌近期效果较好,可减轻不良反应、改善生活质量。更多还原

【Abstract】 Objective To study the recent clinical efficacy of compound matrine injections combined with concurrent chemoradiotherapy in the treatment of locally advanced gastric cancer. Methods Totally 65 cases of untreated locally advanced gastric cancer were randomly divided into treatment group(33 cases) and control group(32 cases). The control group was treated by the conformal intensity modulated radiotherapy combined with chemotherapy. On the basis of the control group, the treatment group was given compound matrine injections 20 m L/time, once a day for 5 weeks. The recent curative effect, the quality of life and adverse reaction of the two groups were observed. Results The recent curative effect rate of the treatment group was 66.67%(22/33), the control group was 40.63%(13/32), the difference was statistically significant(P=0.031). On hematologic toxicity, leukopenia occurred in the treatment group was 30.30%(10/33), the control group was 65.63%(21/32), the difference was statistically significant(P=0.004). KPS of 26 cases(78.79%) improved in the treatment, and 18 cases(56.25%) improved in the control group. Conclusion The effects of compound matrine injections combined with concurrent chemoradiotherapy for locally advanced gastric cancer are good, they can improve short-term efficacy, reduce side effects, and improve the quality of life.更多还原