【摘要】 目的探讨高胆红素血症患儿ABO新生儿溶血病（HDN）（ABO-HDN）的发病率,并分析与ABO-HDN发病相关的因素。方法选择311例高胆红素血症新生儿静脉血标本进行ABO和Rh D血型鉴定及新生儿溶血3项试验检测。结果 311例高胆红素血症新生儿中,确诊ABO-HDN患者97例,阳性率为31.19%,其中直接抗球蛋白试验阳性者56例（57.73%）,游离试验阳性者61例（62.89%）,放散试验阳性者97例（100.00%）。患儿血型A型的阳性率为59.80%（61/102）,高于B型的38.71%（36/93）（χ2=10.230,P<0.05）。ABO-HDN阳性患儿血清总胆红素为（315.27±84.16）μmol·L^-1,高于阴性患儿的（274.52±75.93）μmol·L^-1（t=4.158,P<0.05）。结论高胆红素血症患儿ABO-HDN发病率较高,患儿的血型和血清总胆红素是与ABO-HDN发病密切相关的2个因素。更多还原

【Abstract】 Objective To explore the incidence of ABO hemolytic disease of newborns( HDN)( ABO-HDN) with hyperbilirubinemia and analyze the related factors of ABO-HDN. Methods The venous blood samples of 311 newborns with hyperbilirubinemia were analyzed by ABO and Rh D blood typing and three tests of ABO hemolysis. Results Among 311 cases of hyperbilirubinemia,97 cases were definitely diagnosed with ABO-HDN( 31. 19%),in which the direct antiglobulin test,free antibody test and antibody release test were positive in 56 cases( 57. 73%),61 cases( 62. 89%) and 97 cases( 100. 00%) respectively. The positive rate of patients with type A blood typing( 59. 80%) was higher than type B blood typing( 38. 71%)( χ2= 10. 230,P < 0. 05). The serum total bilirubin value of newborns with ABO-HDN [( 315. 27 ± 84. 16) μmol·L- 1]was significantly higher than that of newborns without ABO-HDN[( 274. 52 ± 75. 93) μmol·L- 1]( t = 4. 158,P < 0. 05). Conclusion ABO-HDN incidence of newborns with hyperbilirubinemia is higher; the blood type and serum total bilirubin values are two closely related factors of ABO-HDN.更多还原