【摘要】 目的:观察探讨急诊经皮冠脉介入治疗(PCI)术前服用美托洛尔是否可降低再灌注心律失常(RA)的发生率。方法:根据随机数字表法,80例急性前间壁心肌梗死(年龄<75岁、基础心率>70次/分、无PR间期延长)患者被随机均分为常规治疗组(急诊PCI前未给予酒石酸美托洛尔片)和美托洛尔组(急诊PCI前给予酒石酸美托洛尔片25mg嚼服)。观察并比较两组术后RA发生率。结果:美托洛尔组中32例行PCI术,8例行经腔经皮冠状动脉血管成形术(PTCA);常规治疗组中35例行PCI,5例行PTCA,两组手术成功率均为100%。美托洛尔组共4例发生RA,包括室颤1例;常规治疗组共15例发生RA,包括室颤4例。美托洛尔组急诊PCI术后RA发生率显著低于常规治疗组(10.0%比37.5%,P=0.032)。结论:急性心肌梗死病人在行急诊PCI术前服用美托洛尔可降低再灌注心律失常发生率。更多还原

【Abstract】 Objective:To explore whether metoprolol administration before emergency percutaneous coronary intervention(PCI)can reduce incidence rate of reperfusion arrhythmia(RA)or not.Methods:According to random number table,a total of 80 patients with acute anterior wall myocardial infarction(age<75years,baseline heart rate>70beats/min,no PR interval prolongation)were randomly and equally divided into routine treatment group(didn’t receive metoprolol tartrate tablet before emergency PCI)and metoprolol group(received metoprolol tartrate tablet 25 mg before emergency PCI).Incidence rate of RA after PCI was compared between two groups.Results:In metoprolol group,a total of 32 cases received PCI and eight cases received percutaneous transluminal coronary angioplasty(PTCA);in routine treatment group,a total of 35 case received PCI and five cases received PTCA,success rates of both groups were 100%.In metoprolol group,RA occurred in 4cases,including one case with ventricular fibrillation(VF);in routine treatment group,RA occurred in 15 cases,including four cases with VF.Incidence rate of RA after emergency PCI in metoprolol group was significantly lower than that of routine treatment group(10.0% vs.37.5%,P=0.032).Conclusion:Metoprolol administration before emergency PCI can reduce incidence rate of reperfusion arrhythmia in patients with acute myocardial infarction.更多还原