Dronedarone is one of the new drugs available for the treatment of atrial fibrillation. The pharmacological effects of the drug are similar to amiodarone,but it does not contain iodine and as such will not cause adverse reactions associated with iodine. The efficacy and safety of dronedarone for the treatment of atrial fibrillation has been extensively studied in clinical research. This paper briefly introduces the clinical status of dronedarone and clinical new prospect,aiming to guide clinical medication.