Objective To observe the protective effects of signal transduction/activation of transcription factor 3( STAT3) on retinal pigment epithelial( RPE) cells against oxidative stress,and explore its role in the pathogenesis of age-related macular degeneration( AM D).Me thods APRE-19 cell lines were cultured in vitro and the oxidative stress injury was induced by oxidized lowdensity lipoprotein( ox-LDL) and H2O2.The rates of proliferation and apoptosis,levels of intracellular reactive oxygen species( ROS) and ce...
【基金】
内蒙古自治区自然科学基金资助项目(编号:2016MS0872)~~
【更新日期】
2016-12-15
【分类号】
R774.5
【正文快照】
年龄相关性黄斑变性(age-related macular degeneration,AMD)是最常见的导致老年患者中央视野缺损的原因之一,也是目前老年人最普遍的致盲原因之一[1-2]。AMD病因形成复杂,是不同疾病所表现出的一种综合征。信号转导和转录激活因子3(signal transduction/activation of transcr
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