【摘要】 目的探究老年Barrett食管与其腺癌患者的临床病理特点。方法回顾性分析2012年1月-2015年1月期间我院收治的60例Barrett食管患者、42例食管胃交界处癌患者和70例食管癌患者的临床资料。分析老年Barrett食管与其腺癌患者的临床病理特点。结果 60例Barrett患者均为短节段柱状上皮,其中有10(16.6%)例伴特异性肠上皮化生,7(11.6%)例伴轻度不典型增生。60例Barrett食管患者均没有进展为食管胃交界处腺癌或者食管腺癌,有2(3.3%)例伴轻度不典型增生的患者发展为重度不典型增生。食管癌主要类型为鳞状细胞癌,其次还有少数小细胞癌、腺癌、腺鳞癌、癌肉瘤、基底细胞样鳞状细胞癌、神经内分泌癌。64.3%的患者发病于食管中段。42例食管胃交界处癌患者主要为食管胃交界处腺癌患者,其中有2(4.8%)例SiewertⅠ型患者,其中1(2.4%)例患者有GERD史,15(35.7%)例SiewertⅡ型患者、25(59.5%)例SiewertⅢ型患者。结论 Barrett食管患者多为短节段柱状上皮,食管癌主要类型为鳞状细胞癌,但Barrett食管患者特异性肠上皮化生和腺癌的发生率均较低,且食管胃交界处癌患者中SiewertⅠ型占少数。更多还原

【Abstract】 Objective To explore Barrett’s esophagus and its clinical and pathological characteristics among old patients alongwith adenocarcinoma. Methods A retrospective analysis was carried out. 60 cases undergoing Barrett’s esophagus,42 cases withesophageal gastroesophageal junction cancer and 70 cases undergoing esophageal cancer in our hospital from January 2012 to January2015 were selected. Data were collected. Clinical and pathological features about Barrett esophageal cancer in old patients were anal-ysed. Results Short segment Barrett columnar epithelium were found in 60 cases,of which ten percent(16.6%)had specific intesti-nal metaplasia and 7(11.6%)patients had mild dysplasia. All 60 cases had no progression of gastroesophageal junction adenocarcino-ma or esophageal adenocarcinoma except that 2(3.3%)patients whose mild atypical hyperplasia were developed into high-grade dys-plasia. The main type of esophageal adenocarcinoma was squamous cell carcinoma,other types included cell carcinoma,adenocarcino-ma,adeno-squamous cell carcinoma,sarcoma cancer,squamous cell carcinoma and neuroendocrine carcinoma. 64.3% of patientswere attacked in the middle part of esophagus. 42 cases of gastroesophageal junction cancer patients were mainly adenocarcinoma pa-tients including 2(4.8%)SiewertⅠ type patients,1(2.4%)cases who had history of GERD,15(35.7%)patients who belonged typeSiewertⅡ patients and 25(59.5%)cases of patients with SiewertⅢ. Conclusion Barrett esophagus mostly are short segment colum-nar epithelium in this study,the main type of it are esophageal squamous cell carcinoma. Furthermore,the incidence of specific intes-tinal metaplasia and adenocarcinoma are low. and the incidence of SiewertⅠ in gastroesophageal junction cancer are low too.更多还原