【摘要】 目的探讨多奈哌齐联合美金刚在阿尔茨海默病高龄患者治疗中的疗效及安全性。方法 40例80~90岁阿尔茨海默病高龄患者随机分成2组,分别接受为期24周的多奈哌齐单药治疗(对照组)或多奈哌齐联合美金刚治疗(联合治疗组),采用ADAS-cog、MMSE、ADL、NPI评价患者治疗后的临床效果以及安全性。结果联合治疗组和对照组在接受24周治疗后的ADAS-cog、MMSE、NPI评分较治疗前均有不同程度的改善,差异具有统计学意义(P<0.05);但两组ADL评分在治疗后的改善与治疗前无统计学差异(P>0.05)。在治疗结束后两组之间的ADAS-cog、MMSE、ADL评分具有差异,但差异无统计学意义(P>0.05);NPI评分上联合治疗组则较对照组改善显著(P<0.05)。联合治疗组发生不良反应显著少于对照组(P<0.05)。结论对于阿尔茨海默高龄患者,多奈哌齐联合美金刚治疗能显著改善患者认知功能和神经精神症状,具有良好的安全性。更多还原

【Abstract】 Objective To discuss the clinical effects and secyrities of donepezil combined with memantine in the treatment of Alzheimer’s disease( AD) in elderly people. Methods 40 cases of 80- 90 years old AD patients were divided into 2 groups randomly. The patients in observation group were treated with donepezil combined with memantine while the patients in control group were accepted donepezil monotherapy for 24 weeks. The ADAS- cog,MMSE,ADL and NPI were used to evaluate the clinical effects before and after treatment. Results 24 weeks later,the scores of ADAS- cog,MMSE and NPI were improved significantly in both groups( P < 0. 05),but there were not significant differences in the scores of ADL( P > 0. 05). After treatment for 24 weeks,there were no significant difference in ADAS- cog,MMSE and ADL between 2groups( P > 0. 05),but the changes in NPI scores in the observation group were significantly improved than in the control group( P < 0. 05). The adverse reaction of observation group was significantly lower than that in control group( P < 0. 05).Conclusion Donepizil combined with memantine can obviously improve the cognitive function and psychological symptoms in the treatment of AD in elderly people,with good security.更多还原