【摘要】 目的探究蓝光对SD大鼠焦虑、抑郁及睡眠的影响。方法动物分为正常光照组、低(100 lx)、中(300 lx)和高(500 lx)剂量蓝光照射组;剥夺蓝光对照组和剥夺蓝光组6个组,低、中、高3个剂量照射组蓝光照射28 d,每天1 h,剥夺蓝光组采用去除蓝光的白光照明饲养28 d。用高架十字迷宫实验、强迫游泳实验及戊巴比妥钠睡眠实验分别观察蓝光照射及去除蓝光对大鼠焦虑、抑郁及睡眠的影响。结果高架十字迷宫实验各项指标组间差异无显著性。蓝光照射中剂量组动物强迫游泳实验中不动时间减少(P<0.05),剥夺蓝光导致不动时间延长(P<0.05);中剂量组在戊巴比妥钠睡眠实验中大鼠睡眠时间延长(P<0.05),剥夺蓝光对戊巴比妥钠睡眠实验结果无明显影响。结论蓝光照射不影响大鼠的焦虑状态,300 lx蓝光照射对大鼠有抗抑郁及促进睡眠的作用,而剥夺蓝光会导致大鼠抑郁。更多还原

【Abstract】 Objective The aim of the study was to explore the influence of blue light on anxiety, depression, and sleep of SD rats. Methods The SD rats were divided into a normal light exposure group, three blue light exposure groups with low(100lx), medium(300lx), and high(500lx) dosages, a blue light deprived control group and a blue light deprived group. The three blue light exposure groups were exposed to blue light 1 h a day for 28 days, and the blue light deprived groups were fed under blue light-eliminated white light for 28 days. The influences of blue light exposure and deprivation on anxiety,depression and sleep of the rats were observed by adopting the elevated plus maze, forced swim, and sodium pentobarbital sleep tests. Results All of the groups showed no significant difference in the elevated plus maze test. In the forced swim test,the medium exposure group had decreased immobility time(P<0.05), while blue light deprivation had shown to prolong the immobility time(P<0.05). In the sodium pentobarbital sleep test, the medium exposure group had extended sleep time(P<0.05), but blue light deprivation had no obvious influence on sleep time. Conclusion Blue light exposure has no effect on anxiety status of the rats. 300 lx of blue light exposure has been shown to suppress depression and promote sleep of the rats,while depriving blue light would lead to depression of the rats.更多还原