【摘要】 背景:研究表明,CD44的表达与胃癌恶性转化具有密切联系。目的:分析肿瘤干细胞表面标志物CD44在胃癌组织中的表达及其临床意义。方法:对92例胃癌患者的术后癌组织标本及30例经病理检查证实为正常胃组织标本进行免疫组化(S-P法)检测,比较两种组织中CD44蛋白的阳性表达率差异,并分析CD44表达与患者预后的关系。结果与结论:(1)胃癌组CD44蛋白的阳性表达率(73%)显著高于正常组(3%),差异有显著性意义(P<0.05);(2)胃癌组CD44蛋白的阳性表达率与患者的临床TNM分期、分化程度、浸润深度、淋巴结转移有显著关系(P<0.05);(3)胃癌组CD44蛋白阳性表达患者3年存活率(37%)显著低于阴性表达患者(64%),差异有显著性意义(P<0.05);(4)TNM分期越高、分化程度越低、淋巴结转移、CD44阳性表达是胃癌患者的独立危险因素(P<0.05),其异常持续性阳性表达可以在一定程度上提示胃癌患者预后不良。更多还原

【Abstract】 BACKGROUND: Studies have shown that CD44 expression is closely associated with malignant transformation of gastric cancer. OBJECTIVE: To study the expression of CD44 in gastric cancer tissues and its clinical significance. METHODS: Gastric cancer specimens from 94 cases of gastric cancer after surgery and normal gastric tissue specimens from 30 cases undergoing gastroscope examination were collected and detected using S-P method. The positive expression rate of CD44 protein in these two groups was compared, and the relationship between CD44 and prognosis was analyzed. RESULTS AND CONCLUSION: The positive expression rate of CD44 protein in the gastric cancer group(73%) was significantly higher than that in the normal group(3%)(P < 0.05). The positive expression rate of CD44 protein in gastric cancer patients was remarkably associated with TNM stage, differentiation degree, invasion depth and lymph node metastasis(P < 0.05). The 3-year survival rate of gastric cancer patients positive for CD44 protein was significantly lower than that of negative patients(P < 0.05). The higher TNM staging indicated the lower differentiation degree, and lymph node metastasis and CD44 positive expression were independent risk factors(P < 0.05). To conclude, the expression of CD44 protein is related to the clinical pathological features and prognosis of gastric cancer patients to some extents.更多还原