【摘要】 背景:在骨水泥中混入抗生素并对人工关节进行固定,能在局部发挥抗生素的抗感染作用,起到预防感染发生的效果。目的:观察含抗生素可活动关节骨水泥对全膝关节置换患者血沉、C-反应蛋白及关节功能的影响。方法:纳入膝关节置换患者86例,其中男43例,女43例,年龄45-75岁,采用随机数字表法分为观察组和对照组,每组43例。观察组采用含抗生素可活动关节骨水泥固定人工膝关节,对照组采用常规骨水泥固定人工膝关节,比较两者手术情况、血液指标、膝关节功能及治疗效果。结果与结论:观察组术后卧床时间、感染发生率明显低于对照组(P<0.05),治疗后2周的屈膝角度、治疗总有效率明显高于对照组(P<0.05)。两组治疗后3,7 d的C-反应蛋白、血沉水平较治疗前明显降低(P<0.05),且观察组低于对照组(P<0.05)。两组治疗后6个月的膝关节功能评分较治疗前显著升高(P<0.05),且观察组高于对照组(P<0.05)。表明含抗生素可活动关节骨水泥有助于预防感染的发生,改善血液指标,促进膝关节功能恢复。更多还原

【Abstract】 BACKGROUND: Antibiotic-loaded bone cement for artificial joint fixation can locally play the anti-inflammatory effects of antibiotics, thereby preventing the occurrence of infection. OBJECTIVE: To investigate the effect of antibiotic-loaded bone cement on erythrocyte sedimentation rate, C-reactive protein and joint function of patients treated by total knee arthroplasty. METHODS: Totally 86 patients, including 43 males and 43 females, aged 45-75 years, were enrolled and divided into observation and control groups(n=43/group). The artificial knee joints of patients in theobservation group were fixed with antibiotic-loaded bone cement, while the artificial knee joints of patients in the in the control group were fixed with conventional bone cement. The surgical condition, blood indexes, knee function and therapeutic efficacy were compared between these two groups. RESULTS ADN CONCLUSION: The bed time and incidence of infection after operation in the observation group were significantly lower than those in the control group(P < 0.05); the knee bending angle and total efficiency of treatment after 2 weeks of treatment were significantly higher than those in the control group(P < 0.05). The C-reactive protein level and erythrocyte sedimentation rate at 3 and 7 days after treatment in these two groups were significantly decreased compared with those before treatment(P < 0.05), especially in the observation group(P < 0.05). The knee joint function scores after 6 months of treatment in these two groups were significantly increased compared with those before treatment(P < 0.05), especially in the observation group(P < 0.05). These results demonstrate that antibiotic-loaded bone cement is conductive to prevent the occurrence of infections, improve blood indexes and promote the knee joint function recovery.更多还原