【摘要】 以易得的十五碳二羧酸为起始原料,经酯化、偶姻缩合环化、甲基化、脱羟基、还原等五步反应以24%的总收率合成了2-甲基环十五酮。该合成路线对大环麝香的合成提供了理论参考和实际应用价值。更多还原

【Abstract】 2-methylcyclopentadecanone was successfully synthesized in total 24% yield via esterification, benzoin condensation cyclization, methylation, dehydroxylation, using 1,15-pentadecanedioic acid as the starting material.Tis synthetic route was theoretical reference and practical value for synthesis of macrocyclic musk.更多还原