【摘要】 目的探究加减左归汤联合阿普唑仑治疗中老年顽固性失眠症患者的效果及其对患者睡眠质量的影响。方法将100例中老年顽固性失眠症患者随机分为对照组50例和观察组50例,分别给予阿普唑仑治疗与加减左归汤联合阿普唑仑治疗,比较2组临床疗效、不良反应及治疗前后匹兹堡睡眠质量指数(PSQI)、抑郁和焦虑状态及中枢神经递质活动情况。结果观察组治疗总有效率显著高于对照组(P<0.05);观察组治疗后各项PSQI评分、焦虑自评量表(SAS)及抑郁自评量表(SDS)评分及兴奋性神经递质总量均显著低于对照组(P均<0.05),抑制性神经递质总量显著高于对照组(P<0.05);2组均未出现严重的不良反应。结论加减左归汤联合阿普唑仑治疗中老年顽固性失眠症可明显改善患者的睡眠质量与抑郁和焦虑状态,安全性高。更多还原

【Abstract】 Objective It is to investigate the effect of Modified Zuogui Decoction( MZD) combined with alprazolam in the treatment of middle aged and elderly patients with intractable insomnia,and observe its influence on the quality of sleep.Methods 100 cases of middle aged and elderly patients with refractory insomnia were randomly divided into control group and observation group with 50 cases in each group. The patients were treated with alprazolam only in control group and MZD combined with alprazolam in observation group. The clinical efficacy,incidence of adverse reaction,Pittsburgh sleep quality index(PSQI),depression and anxiety state,and central neurotransmitter activity of the two groups were observed and compared.Results The total effective rate of the observation group was significantly higher than that of the control group( P < 0. 05); the PSQI,self rating Anxiety Scale( SAS) and self rating Depression Scale( SDS) score,and excitatory neurotransmitter content of the observation group after treatment were significantly lower than those of the control group( all P < 0. 05),the inhibitory neurotransmitters was significantly higher than that of the control group( P < 0. 05); there was no serious adverse reactions in both groups. Conclusion MZD combined with alprazolam can significantly improve the sleep quality of middle aged and elderly patients with refractory insomnia,relieve depression and anxiety state,and with high security.更多还原