【摘要】 目的了解北京市男男性行为者(MSM)中梅毒的新发感染及影响因素,为开展更具针对性、有效性和科学性的预防干预措施提供科学依据。方法 2011年7月至2013年7月完成MSM基线队列招募,运用问卷调查的形式,收集研究对象的社会人口学和性行为情况,并进行梅毒抗体检测。结果 3年内梅毒抗体阴性基线共招募1074名MSM,6个月随访到660人,梅毒新发感染率为6.12/100人年[95%可信区间(CI)=4.09~8.14]。多因素COX回归分析结果显示,研究对象大专以下的文化程度[风险指数(HR)=2.47,95%CI=1.24~4.91,P=0.01],首次与男性发生性关系的年龄(HR=2.24,95%CI=1.04~4.80,P<0.01)和2011-2013年3年内艾滋病病毒检测次数(HR=3.94,95%CI=1.49~10.41,P<0.001)是梅毒血清抗体阳转的影响因素。结论北京市MSM中梅毒新发感染率仍处在较高水平,急需针对梅毒新发感染的相关影响因素开展预防干预工作。更多还原

【Abstract】 Objective To assess syphilis incidence and influencing factors of related risk behaviors among men who have sex with men(MSM) in order to provide the scientific basis for more targeted effective intervention measures.Methods The study was conducted among MSM in Beijing from July,2011 to July,2013,with information of demographic characteristics and sexual behaviors collected via questionnaires and face-to-face interviews.All of the participants received rapid test to detect syphilis.Results 1 074 syphilis sero-negative MSM were recruited as a baseline,and 660 MSM were kept in the cohort during the three years.The seroconversion rate was 6.12 per 100person-years(95%CI:4.09-8.14) for syphilis antibody.Multi-variate Cox regression analysis revealed that education(HR=2.47,95%CI=1.24~4.91,P<0.01),age of MSM having homosexual sex for the first time(HR =2.24,95%CI=1.04~4.80,P<0.01) and the number of HIV rapid tests in the three years(HR = 3.94,95%CI= 1.49~10.41,P<0.01) were independently associated with syphilis infection.Conclusion The syphilis incidence is still at a high level in Beijing.We need to conduct the targeted interventions among MSM based on the related risk factors for syphilis prevention.更多还原