【摘要】 目的:观察托烷司琼对老年髋关节置换术患者术后谵妄发生发展的影响。方法:择期行髋关节置换术老年患者(年龄≥60岁)212例,根据给药情况将患者随机分为托烷司琼组108例和对照组104例。2组均采用全身麻醉,托烷司琼组患者术后5 d内每天静脉注射1次托烷司琼5 mg,对照组为静脉注射0.9%氯化钠溶液。采用意识模糊评估法(CAM)评估2组患者谵妄发生率。谵妄发生后,则分别给予常规护理干预和药物治疗,3 d内观察其疗效。结果:托烷司琼组患者谵妄发生率为5.6%(6例),明显低于对照组的14.4%(15例),差异有统计学意义(P<0.05)。经常规护理干预和治疗后,托烷司琼组6名谵妄患者治愈5例(占83.3%),而对照组15名谵妄患者治愈4例(占26.7%),差异有统计学意义(P<0.05)。结论:托烷司琼能明显降低老年髋关节置换术患者术后谵妄的发生率,并能提高术后谵妄常规治疗的效果。更多还原

【Abstract】 Objective:To observe the effect of tropisetron on the incidence and development of postoperative delirium in elderly patients undergoing hip replacement operation.Methods:According to drug application,212 elderly patients(age≥60 years) undergoing hip replacement operation were randomly divided into tropisetron group(108 cases) and control group(104 cases).General anesthesia were applied in both groups.In tropisetron group,5 mg tropisetron was administered intravenously each day for 5 postoperative days.Control group was given saline solution instead of tropisetron.The rate of postoperative delirium in each group was evaluated by confusion assessment method(CAM).Routine nursing intervention and drug treatment was given to delirium patients in each group,and the curative effect was observed in three days.Results:Incidence of delirium in tropisetron group was 5.6%(6 cases),significantly less than control group 14.4%(15 cases).After routine nursing intervention and drug treatment,5(83.3%) of the 6 delirium patients in tropisetron group were cured,but only 4(14.4%) of the 15 delirium patients in control group were cured.Conclusion:Tropisetron can apparently reduce the incidence rate of postoperative delirium in elderly patients undergoing hip replacement operation and improve the curative effect of conventional treatment of postoperative delirium.更多还原