【摘要】 目的:分析血液透析联合血液灌流的作用,并探讨对维持性透析患者钙磷代谢紊乱的疗效。方法:以本单位2015年全年收治的进行维持性血液透析的患者100例为受试对象,随机分为实验组(50例)和对照组(50例),对照组仅接受血液透析治疗;实验组进行血液透析的基础上联合血液灌流治疗。比较两组患者透析前、透析后2、3、4个月尿素氮(BUN)、肌酐(Scr)、补体C3、β2微球蛋白(β2-MG)、血磷(P)、钙磷乘积、血清全段甲状旁腺激素(i PTH)、维生素D3(1,25(OH)D3)的水平,比较两组患者血清白蛋白(Alb)、胆固醇(TC)、血红蛋白(Hb)、红细胞水平(RBC),并分析其临床意义。结果:两组患者透析后各时间段BUN、Scr水平均较透析前显著降低,补体C3水平则在透析4个月后显著升高;而两组患者透析后各时间段肾功能评价指标无显著差异;实验组各时间段钙磷代谢指标较透析前和对照组显著改善;实验组透析后3、4个月营养状况较透析前、对照组均有所改善,对照组营养状况无显著差异。结论:血液透析联合血液灌流有助于维持性血液透析患者体内毒素的清除,纠正钙磷代谢紊乱,改善患者营养状况,值得推广使用。更多还原

【Abstract】 Objective: To analyze the importance of hemodialysis combined with hemoperfusion, and discuss the efficacy on the treatment of phosphorus and calcium metabolism disorder in the patients of maintenancing hemodialysis. Methods: All of the patients treated with maintenancing hemodialysis in our hospital during 2015 were selected. A summary of 100 patients with chronic renal failure were chosen and randomly classified into the control group(n=50) and the experimental group(n=50). The control group were treated with hemodialysis, Whileexperimental group were treated with hemodialysis combined with hemoperfusion. The serum concentration of BUN, Scr, complement C3, β2-MG, P, Ca and P product, i PTH, 1,25(OH)-D3, Alb, TC, Hb, RBC between the two groups were compared. Results: BUN, Scr, complement C3, β2-MG in two groups were improved significantly, while no statistical difference were found between the two groups; The indicators of phosphorus and calcium metabolism in experimental group at post-therapy became better than that in pre-therapy and in posttherapy of the control group. The indicators of nutritional status in experimental group at 3, 4 months after therapy were better than that of pre-therapy and the control group. There was no significant difference in the nutritional status of the control group. Conclusion: The hemodialysis combined with hemoperfusion can help flush out toxins and correct the disorder of calcium and phosphorus metabolism and improve the nutritional status, it’s worthy of clinical promotion.更多还原