【摘要】 过去的几十年里,虽然对衰老的氧化应激理论进行了广泛的研究,但是目前仍然存在着许多争议,特别在哺乳动物中。最近关于硫氧还蛋白-1(Trx1)在氧化应激和衰老中的研究提示:1)氧化应激及后续信号通路的改变可能在不同年龄阶段有着不同的病理生理作用;2)与氧化损伤的累积相比,氧化应激和氧化还原状态导致氧化还原敏感信号通路的改变可能在衰老的病理生理中扮演着更重要的角色。因此,本文对硫氧化蛋白-1与衰老的关系进行简述。更多还原

【Abstract】 Over the past several decades, in spite of intensive study, there is still controversy about the oxidative stress theory of aging, particularly in mammals. Recently, studies on the role of thioredoxin on oxidative stress and aging indicate that: 1) oxidative stress and subsequent changes in signalling pathways could have different pathophysiological impacts at different stages of life; 2) changes in redox-sensitive signalling controlled by levels of oxidative stress and redox state could play more important roles in pathophysiology than accumulation of oxidative damage. To critically test the role of oxidative stress on aging and investigate changes in redox-sensitive signalling pathways, further study is required.更多还原