Objective To set up the three-dimensional structure of NSP1 C-terminal effector domain in rotavirus and IRF association domain( IAD) of interferon regulatory factors by homologous modeling,and to predict the candidate residues of NSP1 binding to IRF by molecular docking technique. Methods Using the Prot Scale method,we predicted the hydrophobicity for NSP1. The electrostatic potential of NSP1 and IRF3,IRF5,IRF7 was determined by APBS method. While comparing amino acid sequences with other proteins,the three...
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