【摘要】 目的探讨某院常用的3种抗菌药物使用方案预防胆囊炎围手术期感染的疗效和经济学差异,为临床肝胆外科手术合理使用抗菌药物提供参考。方法对341例预防性使用抗菌药物的胆囊炎采用腹腔镜胆囊切除术治疗患者的病历进行回顾性分析,筛选出符合要求的192份病历,运用成本-效果分析进行药物经济学评价。结果 A、B、C三组的显效率分别为96.74%、96.05%、95.83%,成本分别是1753.44元、635.22元、574.66元,成本效果比(C/E)分别为18.13、6.61、6.00,A、B组方案对于C组的增量成本效果比(△C/△E)分别为1295.36、275.27。结论:C组是预防胆囊炎围手术期感染最经济的方案。但鉴于《2015年抗菌药物临床应用指导原则》指出,应严格控制氟喹诺酮类药物作为外科围手术期预防用药,因此B组是最佳方案。更多还原

【Abstract】 Objective To discuss the difference of 3 approachs of using antibacterial drugs to prevent infection during cholecystitis’ perioperative period in effectiveness and economics,and to provide reference for rational use of antibacterial drugs in biliary disease surgery.Methods The 341 cases of cholecystitis by laparoscopic cholecystectomy for the treatment were retrospectively analyzed,and then 192 cases which meet requirements are filtered.Finally,we use the cost-effectiveness analysis to evaluate the 3approachs in pharmacoeconomics.Results:Effective rates of the three kinds of therapeutic schedules are 96.7%,96.05%and 95.83%.Costs respectively are 1753.44,635.22 and 574.66 yuaaConclusion Group A is the most economical choice for preventing infection compared with Group B and C.But the Guidelines for Clinical Use of Antibacterials suggests that the fluoroquinolone drags as a surgical perioperative prophylaxis should be strictly controlled.Thus,therapy B is preferable.更多还原