【摘要】 目的研讨急性脑梗死患者运用两种不同剂量阿托伐他汀治疗的临床价值。方法从我院2014年12月至2015年12月收集的急性脑梗死患者中随机选取260例进行分组研究,Ⅰ组130例接受阿托伐他汀20mg治疗,Ⅱ组130例接受阿托伐他汀40mg治疗,连续治疗4周后,评估该两种方案的安全性及其对患者血脂、CRP等指标的改善效果。结果 (1)基线期,两组的TC、TG及HDL-C等血脂指标水平经软件分析,统计学不成立(P>0.05),治疗4周后,Ⅱ组的TC值(4.40±0.84)mmol/L,显著比Ⅰ组的(4.57±0.91)mmol/L下降,统计学成立(P<0.05),但其余指标比较统计学不成立(P>0.05)。(2)两组基线期的血清CRP与NIHSS量表评测结果经分析,统计学不成立(P>0.05),治疗后,Ⅱ组的CRP指标与NIHSS量表评测结果相比Ⅰ组均显著改善,统计学成立(P<0.05)。结论阿托伐他汀对急性脑梗死具有确切药效,且高剂量(40mg/d)给药安全,降脂、抗炎效果好,值得推荐。更多还原

【Abstract】 Objective:To study the clinical value of two patients with acute cerebral infarction by using different doses of atorvastatin therapy.Methods Collected from our hospital in December 2014 to December 2015 in patients with acute cerebral infarction were randomly selected 260 cases were divided into two groups and studied,group Ⅰ 130 patients received atorvastatin,simvastatin 20 mg treatment,the improvement effect.Results Baseline period,two groups of TC,TG and HDL-C blood lipid level through software analysis,was not established(P>0.05),after 4 weeks of treatment,group Ⅱ of the TC value(4.40 + 0.84 mmol / L) significantly than group Ⅰ(4.57 + 0.91) mmol / L decreased,statistically founded(P < 0.05),but other indicators statistical comparison was not established(P> 0.05).Conclusion Atorvastatin has definite efficacy on acute cerebral infarction(40mg/d),and high dose of medication safety,lipid-lowering,anti-inflammatory effect is good,worthy of recommendation.更多还原