【摘要】 目的观察中药联合肝动脉灌注化疗栓塞术(transcatheter arterial chemoembolization,TACE)对原发性肝癌患者免疫功能的影响。方法原发性肝癌80例被分为治疗组(中药联合TACE组,40例)和对照组(TACE组,40例)。两组均于TACE术前24 h、术后1周和4周,检查外周血T淋巴细胞亚群、CD4CD25调节性T淋巴细胞(Treg),以及AFP含量,并进行临床疗效及生活质量评分(KPS)比较。结果治疗1周后,对照组CD3+[(45.26±2.83)vs(50.16±6.31)]、CD4~+[(22.65±2.35)vs(27.12±3.36)]、CD4~+/CD8~+[(0.85±0.16)VS(1.16±0.27)]较术前降低,CD8~+[(32.48±6.21)vs(27.36±5.64)]及CD4~+CD25~+[(12.65±5.12)vs(9.15±3.63)]调节性T淋巴细胞(Treg)呈升高趋势,差异有统计学意义(P<0.05);治疗组CD3+[(46.55±3.94)vs(49.33±3.12)]、CD4~+[(23.13±2.72)vs(25.53±2.52)]、CD8~+[(25.26±3.52)vs(27.69±5.13)]、CD4~+/CD8~+[(1.13±0.39)vs(1.22±0.16)]及Treg细胞[(10.36±5.62)vs(8.20±2.25)]较治疗前变化无统计学意义(P>0.05)。治疗4周后,两组患者T细胞亚群各项指标均较术前明显改善(P<0.05),组间比较差异无统计学意义(P>0.05);Treg细胞组间比较,治疗组优于对照组[(3.96±1.32)vs(6.21±3.42)],有统计学意义(P<0.05)。AFP测定及KPS评分,治疗组均优于对照组。结论中药联合TACE可以更好的改善原发性肝癌患者的免疫状况及生活质量。更多还原

【Abstract】 Objective To explore the influence of Traditional Chinese Medicine combined with transcatheter arterial chemoembolization( TACE) on immune function in primary liver cancer patients. Methods A total of 80 patients with pathologicallyproved PLC were enrolled in this study,and randomly divided into a study group and a control group. The study group was treated with TCM combined TACE,while the control group was treated by TACE alone. Peripheral blood T lymphocyte subsets cells,AFP,CD4~+CD25~+Treg cell,as well as the therapeutic effect,Karnofsky sore( KPS) were determined 24 h before treatment and one,and 4weeks after treatment. The results were statistically analyzed. Results At the end of the first week after treatment,the preoperative peripheral T lymphocyte subsets CD3+( 45. 26 ± 2. 83) vs( 50. 16 ± 6. 31),CD4~+( 22. 65 ± 2. 35) vs( 27. 12 ± 3. 36) T cells and CD4~+/ CD8~+( 0. 85 ± 0. 16) vs( 1. 16 ± 0. 27) in the study group were significantly lower,while CD8~+( 32. 48 ± 6. 21) vs( 27. 36 ±5. 64) T cells,CD4~+CD25~+( 12. 65 ± 5. 12) vs( 9. 15 ± 3. 63) Treg cells were significantly higher than that before treatment( P <0. 05). However,in control group,the peripheral T lymphocyte subsets CD3+,CD4~+,CD8~+T cells and CD4~+/ CD8~+were not statistically significantly different. After 4 weeks,for two groups,the peripheral T lymphocyte subsets CD3+( 46. 55 ± 3. 94) vs( 49. 33 ±3. 12),CD4~+( 23. 13 ± 2. 72) vs( 25. 53 ± 2. 52),CD8~+( 25. 26 ± 3. 52) vs( 27. 69 ± 5. 13) T cells and CD4~+/ CD8~+( 1. 13 ±0. 39) vs( 1. 22 ± 0. 16) were significantly different( P < 0. 05). Treg cells,AFP,KPS were statistically significantly different when compared with those in the control group( P < 0. 05). Conclusions TCM combined with TACE can enhance the immunity and quality of life in patients with primary liver cancer.更多还原