Natural bone is an outcome of a multi-template co-assembly process. Compared to single-template selfassembly, bone-like apatite induced by bi-template exhibits more common features and similarities of natural bone that has attracted a wide attention in field of biomineralization. This paper summarizes the recent research achievements in bi-template-induced biomimetic self-assembled apatite. The design of bi-template molecule and the interactions between the molecular templates have been investigated as well...