【摘要】 鸟苷酸环化酶C(GCC)作为一种肠道组织特异性多肽,在肠黏膜上皮细胞表达,同时表达于结直肠癌细胞株以及原发性和转移性结直肠癌。研究表明检测血液中GCC mRNA可早期发现结直肠癌的临床转移和复发,有益于治疗方案的制定与治疗后的随访复查。本文就GCC与结直肠癌诊断和治疗的研究进展作一综述。更多还原

【Abstract】 Guanylyl cyclase C( GCC) is a specific intestinal tissue polypeptide expressed in intestinal epithelial cells,and is also expressed in colorectal cancer cell line and primary and metastatic colorectal cancer. Studies have indicated that level of GCC mRNA in blood could contribute to the early detection of colorectal cancer metastasis and recurrence,and is beneficial to the formulation of therapeutic regimen and follow-up. This article reviewed the progress in research on GCC in diagnosis and treatment of colorectal cancer.更多还原