【摘要】 目的探讨c AMP反应元件结合蛋白基因多态性与中国北方汉族人群精神分裂症之间的关系。方法据《精神障碍诊断与统计手册(第4版)》(DSM-IV)诊断标准收集山西省荣军精神康宁医院和山西医科大学第一医院精神卫生科门诊及住院部符合精神分裂症诊断标准的患者为研究组,同期收集符合入组标准且不符合排除标准的健康成年人为对照组,运用连接酶检测-聚合酶连锁反应(LDR-PCR)方法检测1 230例精神分裂症患者和1 120例健康成年人的CREB基因上单核苷酸多态性(SNP)rs6740584及rs10932201的等位基因和基因型分布情况,确定其与精神分裂症是否相关。结果 rs6740584位点的基因型和等位基因在研究组和对照组间差异均无统计学意义(χ~2=1.236,P=0.266;χ~2=2.720,P=0.257);rs10932201位点的基因型和等位基因在研究组和对照组间差异均无统计学意义(χ~2=2.017,P=0.156;χ~2=3.779,P=0.151);两组rs6740584与rs10932201在不同模型下的频率分布均无统计学意义(P均>0.05)。结论 CREB基因rs6740584及rs10932201多态性与中国北方汉族人群精神分裂症无关联。更多还原

【Abstract】 Objective To explore the association between a polymorphism in the promoter region of the c AMP( response element binding protein) gene and schizophrenia in north han Chinese patients. Methods Recruited inpatients and outpatients who conform to the diagnostic criteria of schizophrenia with DSM- IV from Shanxi Rongjun Psychiatric Corelle Hospital and First Hospital of Shanxi Medical University were study group,at the same time,collected health adults formed the control group. Ligase Detection Reaction- Polymerase Chain Reaction( LDR- PCR) was used to detect the rs6740584 and rs10932201 polymorphism of CREB in 1 230 schizophrenia patients and 1 120 health adults. The allele,genotype distribution and different model of CREB gene SNP were detected to determine the association between CREB and schizophrenia. Results No significant distribution difference of the genotype and allele of rs6740584 and rs10932201 of CREB were found between two groups( χ~2= 1. 236,P = 0. 266; χ~2= 2. 720,P = 0. 257; χ~2= 2. 017,P = 0. 156; χ~2= 3. 779,P = 0. 151). Conclusion No association is found between CREB SNP rs6740584 or rs10932201 and schizophrenia in north han Chinese population sample.更多还原