【摘要】 目的通过对热毒宁、痰热清、炎琥宁、细辛脑、双黄连5种中药针剂在儿科临床用药过程中出现的不良反应分析,查找药物不良反应相关因素,为儿科临床安全用药提供参考。方法本院2006年1月到2015年9月儿科0~6岁住院患儿回顾性统计热毒宁、痰热清、炎琥宁、细辛脑、双黄连5种针剂出现的不良反应130例。结果药物不良反应因素包括患者因素、药物因素和使用因素。在5种中药针剂双黄连、细辛脑出现不良反应较多,占67%,不良反应最常见表现形式为皮肤损害,占64%,其次为全身性反应占17.7%,严重不良反应占13%,多为过敏性休克。结论儿科应高度重视中药针剂在儿科应用中的不良反应报告及监测工作,严格遵循使用原则,保障患儿用药安全,促进临床合理用药。更多还原

【Abstract】 Objective: To find the related factors of adverse drug reaction,and provide reference for pediatric clinical medication safety. Methods: The 130 cases retrospective statistical analysis was made of adverse reactions of Reduning,Tanreqing,Yanhuning,asarone and Shuanghuanglian from 0 to 6 years old pediatric hospitalized children in our hospital from January,2006 to September 2015. Results: Adverse drug reaction factors included patient factors,drugs and the use of drugs. In 5 kinds of traditional Chinese Medicine injection,Shuanghuanglian and asarone had more adverse reactions,accounting for 67%. Adverse reactions of the most common manifestation were skinlesions,accounting for 64%,followed by systemic reactions accounting for 17. 7%. Serious adverse reactions accounting for 13% are mostly anaphylactic shock.Conclusion: Doctors of pediatrics should attach great importance to the reports of adverse reactions about the traditional Chinese medicine injection in pediatric applications and supervision,strictly follow the principles,guarantee children’s medication safety and promote rational drug use in clinic.更多还原