【摘要】 对地胆草全草的化学成分进行研究。采用硅胶柱色谱、Sephadex LH-20以及半制备型高效液相色谱技术进行分离纯化,通过1D、2D NMR,MS等方法鉴定化合物的结构。结果从地胆草95%乙醇提取物中分离并鉴定了9个化合物,分别为1-[(2R*,3S*)-3-ethoxy-2,3-dihydro-6-hydroxy-2-(1-methylethenyl)-1-benzofuran-5-yl]ethanone(1)、7-hydroxy-6-acetyl-2-methylchromone(2)、matriisobenzofuran(3)、桦木酸(betulinic acid,4)、木犀草素(luteolin,5)、木犀草素-7-O-β-D-葡萄糖苷(luteolin-7-O-β-D-glucoside,6)、对香豆酸(p-coumaric acid,7)、3,4-二羟基苯甲醛(3,4-dihydroxy benzaldehyde,8)、豆甾醇-3-O-β-D-葡萄糖苷(stigmasterol-3-O-β-D-glucoside,9)。其中化合物1~3均为首次从该属植物中分离得到,化合物3在国内未见从其它植物中分离报道。更多还原

【Abstract】 To study the chemical constituents of Elephantopus scaber L. The isolation of ingredients was performed by chromatography on silica gel,Sephadex LH-20 and semi-preparative HPLC. Nine compounds were obtained from the95% ethanol extract of E. scaber based on 1D,2D NMR,MS spectroscopic methods. Their structures were obtained and identified as 1-[( 2R*,3S*)-3-ethoxy-2,3-dihydro-6-hydroxy-2-( 1-methylethenyl)-1-benzofuran-5-yl]ethanone( 1),7-hydroxy-6-acetyl-2 methylchromone( 2),matriisobenzofuran( 3),betulinic acid( 4),luteolin( 5),luteolin-7-O-β-D-glucoside( 6),p-coumaric acid( 7),3,4-dihydroxy benzaldehyde( 8) and stigmasterol-3-O-β-D-glucoside( 9). Compounds 1-3were isolated from the genus for the first time. The compound 3 was not reported from other plants in domestic.更多还原