【摘要】 为提高大黄酚(Chr)的水溶性和生物利用度,旨在找出一种适合大黄酚-β-葡聚糖超分子复合物(Chr-β-glu)的制备方法,为制剂加工和贮存研究提供依据。分别采用饱和溶液法、共研磨法、冷冻干燥法、电磁搅拌-喷雾干燥法(ES)和共沉淀法等方法制备Chr-β-glu,以包封率、渗漏率和累积释放率为评价指标,选出最适合Chr-β-glu的制备方法。电磁搅拌-喷雾干燥法处理可以显著提高大黄酚-β-葡聚糖超分子包合物的平均包封率和累积释放率,明显优于其他方法;共沉淀法制备的Chr-β-glu的平均渗漏率最低,但与ES法制备相比没有显著性差异。采用电磁搅拌-喷雾干燥法制备的大黄酚-β-葡聚糖超分子包合物具有较高的包封率和稳定性,作为药物载体,其在医药、食品和日化工业中具有广泛的应用前景。更多还原

【Abstract】 To improve the solubility and bioavailability of chrsophanol( Chr) and provide the foundation for preparation,processing and storage of new formulations,five preparation methods of supermolecular inclusion complex of Chr and β-glucan( Chr-β-glu) were compared. The inclusion complex of Chr-β-glu prepared by saturated solution method,co-grinding method,freeze drying method,electromagnetic stirring-spray drying( ES) method and co-precipitation method,respectively,was compared based on the index of encapsulation efficiency,percolation rate and cumulative release rate. The results showed that the encapsulation efficiency and cumulative release rate of Chr-β-glu prepared by ES method was higher than samples prepared by other preparation methods. The percolation rate of Chr-β-glu prepared by co-precipitation method was lower than samples prepared by other preparation methods. However,the percolation rate was of no significant difference between ES method and co-precipitation method. The supermolecular inclusion complex of Chr and β-glucan had higher encapsulation efficiency and better stability. It will be widely applied in medicinal,food and daily chemical industries.更多还原