【摘要】 目的研究IGF-Ⅱ、IGF-ⅠR在早期宫颈癌中的表达及其临床意义。方法收集石河子大学医学院一附院自2013年5月至2014年6月确诊为早期宫颈癌的患者50例作为观察组,另选取50例因子宫肌瘤行全子宫切除的患者作为对照组,比较观察组与对照组中IGF-Ⅱ、IGF-ⅠR免疫组化检测的阳性表达率,以及在早期宫颈癌患者中绝经与未绝经,临床分期中Ⅰb与Ⅱa,组织学分级Ⅰ、Ⅱ、Ⅲ,脉管内有无癌栓,淋巴结有无转移者的IGF-Ⅱ、IGF-ⅠR阳性表达率的情况。结果观察组中的IGF-Ⅱ与IGF-ⅠR阳性表达率均高于对照组,且双阳性表达率也高于对照组,差异具有统计学意义(均P<0.05);早期宫颈癌患者中绝经妇女的IGF-Ⅱ与IGF-ⅠR阳性表达率均低于未绝经妇女,但差异无统计学意义(P>0.05);Ⅱa期患者的IGF-Ⅱ与双阳性表达率明显高于Ⅰb期患者,差异具有统计学意义(均P<0.05),在IGF-ⅠR阳性表达率中差异无统计学意义(P>0.05);组织学分级Ⅰ、Ⅲ级患者的IGF-Ⅱ与IGF-ⅠR阳性表达率及双阳性表达率均高于Ⅱ级患者,但差异无统计学意义(均P>0.05);脉管内有癌栓的患者IGF-Ⅱ与IGF-ⅠR阳性表达率及双阳性表达率均高于无癌栓的患者,差异无统计学意义(均P>0.05);有淋巴结转移的患者IGF-Ⅱ与IGF-ⅠR阳性表达率及双阳性表达率明显高于无淋巴结转移患者,差异有统计学意义(均P<0.05)。结论在早期宫颈癌患者中IGF-Ⅱ和IGF-ⅠR的表达与妇女的生理状况、病情程度以及组织学分级等存在着密切的关系。更多还原

【Abstract】 Objective To investigate the expression of IGF-Ⅱ and IGF-ⅠR in early cervical cancer and its clinical significance.Methods A total of 50 patients with early cervical cancer diagnosed in the First Affiliated Hospital of Medical College of Shihezi University between May 2013 and June 2014 were enrolled as observation group and another 50 patients with uterine fibroids who underwent total hysterectomy served as controls.The expression levels of IGF-Ⅱ and IGF-ⅠR in both groups were determined by immunohistochemistry.The association of the expression of IGF-Ⅱ and/or IGF-ⅠR was examined with clinical and pathologic characteristics of early cervical cancer,including menopausal status,clinical stages(Ⅰb and Ⅱa),histological grades(Ⅰ,Ⅱ,Ⅲ),the presence or absence of lympho-vascular cancer embolus or lymph-node metastasis.Results The positive rate of the expression of either IGF-Ⅱ,IGF-ⅠR alone or both was significantly higher in observation group than that in control group(P<0.05).In early cervical cancer patients,menopausal women had lower expression of IGF-Ⅱ and IGF-ⅠR than nonmenopausal women,but the difference was not significant(P>0.05).The expression rate of IGF-Ⅱ and the co-expression rate of IGF-Ⅱ and IGF-ⅠR were profoundly higher in patients atⅡa stage than in those atⅠb stage(P<0.05).The expression rates of IGF-Ⅱ and IGF-ⅠR and their co-expression rate were increased in patients with histological gradeⅠorⅢ,or lymphovascular cancer embolus when compared with those at histological gradeⅡor without cancer embolus but no significant differences were found(P>0.05).Patients with lymph-node metastasis had higher positive expression rates of either IGF-Ⅱ,IGF-ⅠR lone or both than those without lymph-node metastasis(P<0.05).Conclusion The expression of IGF-Ⅱand/or IGF-ⅠR is closely associated with the physiological status,severity and histological grades of patients with early cervical cancer.更多还原